Free live seminar on Issues in MRD Detection by Flow Cytometry. Hear Mike Keeney, former Hematology Scientific Committee Chair, in his talk on the importance of flow cytometry in the identification and characterization of hematological cancers. Receive Continuing Medical Education and CE Credits.
Issues in MRD Detection by Flow Cytometry
May 30, 2013 8:00-9:00AM PST
Michael Keeney, ART, FIMLS, FCSMLS(D)
Coordinator, Flow Cytometry, Hematology, Associate Scientist
Lawson Health Research Institute
London Health Sciences Centre Victoria Hospital
Flow cytometry (FC) has become an essential tool for identification and characterization of hematological cancers and due to technological improvements, allows the identification and rapid enumeration of small tumor populations that may be present after therapy (minimal residual disease, MRD). The quantification of MRD has been shown to correlate with relapse and survival rates in the acute leukemias.
This presentation will focus mainly on the technical issues that need to be considered when counting such rare events, were the distribution is governed by Poisson statistics, with precision increasing with higher numbers of cells collected. Standardized approaches in sample preparation and analysis for specific disease states must be developed to ensure precise identification and enumeration of rare abnormal populations that have the potential to alter the course of patient treatment.
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